Yale University · GeneticsLaboratory for Chromatin Dynamics and Development
Valerie J Reinke · New Haven, Connecticut
Research Focus
Dr. Valerie J. Reinke's research focuses on understanding how the organization of chromatin in germ cells influences embryonic development. By studying the roundworm C. elegans, her lab aims to uncover the mechanisms that regulate gene expression and chromatin dynamics during key processes like fertilization and early development. These insights could have important implications for understanding genetic regulation in humans and addressing developmental diseases.
C. eleganschromatin organizationembryogenesisgene expressionepigeneticsgametogenesisnucleosome remodelingpiRNA biogenesisgenomic analysisdevelopmental biology
Research Aims
5AIM 01Investigate chromatin organization in the C. elegans germ line.
AIM 02Explore the role of histone modifications in gene expression.
AIM 03Define novel chromatin states and their effects on embryogenesis.
AIM 04Discover mechanisms of nucleosome remodeling during fertilization.
AIM 05Analyze the relationship between chromatin dynamics and cellular function in development.
Skills the Lab Values
DNA extractionmolecular cloninggene expression analysisgenomic sequencingCRISPRWestern blottingRNA isolationimmunofluorescencemicroscopychromatin immunoprecipitation
Output against the department
Publications715top 7% of dept.17th of 259
this lab
most publishedleast published
Citations10ktop 49% of dept.127th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.