Tufts University · Microbiology & ImmunologyRegulatory T Cell Research Lab
Xudong Li · Medford, Massachusetts
Research Focus
Dr. Xudong Li's research lab focuses on understanding how certain cellular processes affect the function and fitness of regulatory T cells, which are essential for maintaining a healthy immune response. The lab particularly investigates the role of heme synthesis, an important biological process, in controlling these T cells' abilities to prevent autoimmune diseases. By studying the effects of a specific enzyme on Treg cells, the goal is to develop new therapies that could enhance the body's natural defenses against autoimmune disorders.
regulatory T cellsautoimmune diseasesheme synthesisCRISPRT cell functionEAE modelimmunotherapy
Research Aims
2AIM 01Determine how the enzyme Cpox promotes the fitness and suppressive function of Effector T cell Reprogrammed Tregs.
AIM 02Explore the regulatory pathways controlling Cpox expression in Tregs and its impact on Treg dysfunction in autoimmunity.
Skills the Lab Values
CRISPRcell culturemouse modelsgene expression analysisflow cytometryWestern blotoxidative phosphorylation analysisepigenetic reprogrammingadoptive T cell transfer
Output against the department
Publications517top 5% of dept.25th of 486
this lab
most publishedleast published
Citations11ktop 35% of dept.168th of 486
this lab
most citedleast cited
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