Stanford University · Microbiology & ImmunologySalmonella Host Interaction Lab
Denise M Monack · Stanford, California
Research Focus
Dr. Denise M Monack's lab at Stanford University focuses on understanding how Salmonella bacteria survive and persist within the host's immune system. They study the interactions between Salmonella and immune cells, particularly macrophages and eosinophils, which play crucial roles in the bacteria's ability to cause disease. By investigating the mechanisms of bacterial persistence in lymph nodes and exploring factors that influence immune responses, the lab aims to identify new strategies for preventing and treating Salmonella infections.
Salmonellagranulomamacrophageseosinophilsinfectious diseasetyphoidal Salmonellahost-pathogen interactionsvirulence factors
Research Aims
5AIM 01Investigate how Salmonella Typhimurium survives in mesenteric lymph nodes.
AIM 02Characterize interactions between eosinophils and Salmonella in vitro and in vivo.
AIM 03Discover immune regulatory functions of eosinophils related to Salmonella persistence.
AIM 04Identify unique virulence factors of typhoidal Salmonella in macrophages.
AIM 05Analyze the metabolic profile of macrophages infected with Salmonella.
Skills the Lab Values
cell culturein vivo modelsmolecular biology techniquesbioinformaticstranscriptional profilingspatial transcriptomicsimmunoassayspathogen infection assayssequencing technologiesdata analysis
Output against the department
Publications199top 32% of dept.156th of 486
this lab
most publishedleast published
Citations28ktop 11% of dept.54th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.