UMCUniversity of Massachusetts Chan Medical School · Biology
Adipose Metabolism Research Lab
Silvia Corvera · Worcester, Massachusetts
Research Focus
Dr. Silvia Corvera's lab focuses on understanding how human adipose (fat) tissue regulates metabolism and energy balance, especially in the context of diseases like Type 2 Diabetes. By studying the activities of different types of human fat cells in laboratory models, they aim to uncover the mechanisms that control fat storage and energy expenditure, which are crucial for preventing metabolic disorders. Their groundbreaking research includes techniques to develop functional human fat in mice, allowing for innovative studies on fat cell behavior and the effects of specific genes on metabolism.
adipose tissuemetabolismType 2 Diabetesfat cell biologythermogenesis
Research Aims
3AIM 01Investigate how human adipocyte MAOA affects responses to norepinephrine in fat cells.
AIM 02Evaluate the role of MAOA in the development and function of thermogenic adipose tissue in living organisms.
AIM 03Determine the influence of adipocyte MAOA expression on obesity and glucose metabolism in mouse models influenced by varied fat cell origins.
Skills the Lab Values
CRISPR-Cas9cell culturemouse modelslipolysis assessmentthermogenesis measurement
Output against the department
Publications169top 39% of dept.407th of 1,033
this lab
most publishedleast published
Citations13ktop 28% of dept.289th of 1,033
this lab
most citedleast cited
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