University of California-Irvine · PhysiologyMarangoni Immunotherapy Lab
Francesco Marangoni · Irvine, California
Research Focus
Dr. Francesco Marangoni's lab at UC Irvine focuses on understanding how certain cancer treatments, specifically checkpoint blockade immunotherapy, can sometimes fail due to the body's immunosuppressive responses. By studying the role of immune cells called T regulatory cells and how different tumor environments affect them, the lab aims to identify strategies to enhance the effectiveness of these therapies. Their ultimate goal is to improve cancer treatment options for patients who currently see little benefit from existing therapies.
checkpoint blockade immunotherapyimmunosuppressionT regulatory cellstumor microenvironmentcancer therapy
Research Aims
5AIM 01Investigate how PD-1 blockade influences T regulatory cell support in tumors.
AIM 02Identify the spatial organization of immune cells in response to dual checkpoint blockade.
AIM 03Explore resistance mechanisms associated with CTLA-4 and other checkpoint inhibitions.
AIM 04Assess the impact of various antigens on immune response post PD-1 blockade.
AIM 05Develop strategies to overcome immunosuppression to improve cancer immunotherapy outcomes.
Skills the Lab Values
flow cytometryRNA sequencingintravital microscopyhigh-resolution spatial sequencinganimal models
Output against the department
Publications79bottom 19% of dept.233rd of 286
this lab
most publishedleast published
Citations4.7kbottom 40% of dept.171st of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.