WMCWeill Medical College of Cornell University · Biology
SPOP Signaling and Prostate Cancer Unit
Pengbo Zhou · New York, New York
Research Focus
Dr. Pengbo Zhou's lab focuses on understanding how specific mutations in the SPOP gene influence the development and progression of prostate cancer. By exploring both upstream regulators and downstream effects of this signaling pathway, the lab aims to identify new treatment strategies that target specific cancer subtypes, particularly those that display unique responses to therapy. This research is crucial for creating more effective, personalized medical interventions for patients with prostate cancer.
prostate cancerubiquitin signalingSPOPandrogen receptortherapeutic targetinggene mutationscancer subtypesprecision medicinetumorigenesisdrug development
Research Aims
2AIM 01Define the role of G3BP1 in prostate tumorigenesis using model systems and human samples.
AIM 02Establish the therapeutic potential of targeting the SPOP signaling axis by modulating downstream effectors.
Skills the Lab Values
cell culturegenetically engineered mouse modelsWestern blotRNA sequencingin vitro assaysdrug screeningmolecular cloningprotein analysisbiological modelingdata analysis
Output against the department
Publications144top 47% of dept.486th of 1,033
this lab
most publishedleast published
Citations5.6kbottom 41% of dept.608th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.