WMCWeill Medical College of Cornell University · Microbiology & Immunology
Tuberculosis Drug Resistance Lab
Dirk Schnappinger · New York, New York
Research Focus
Dr. Dirk Schnappinger's lab at Weill Medical College focuses on understanding tuberculosis (TB), a major global health issue. The lab investigates the mechanisms of new antibiotics called nitroimidazoles, which are essential for treating drug-resistant TB. By studying the genetics and metabolism of the TB bacteria, the team aims to enhance treatment strategies and develop more effective drugs.
Mycobacterium tuberculosisnitroimidazolesdrug resistancechemotherapygenomic approachesanimal models
Research Aims
5AIM 01Identify genes in Mycobacterium tuberculosis that affect the potency of nitroimidazoles.
AIM 02Analyze the mechanisms by which nitroimidazoles kill TB bacteria.
AIM 03Investigate the roles of drug resistance and tolerance in TB treatment.
AIM 04Develop improved treatment regimens for drug-resistant tuberculosis.
AIM 05Combine biochemical and genetic approaches to enhance understanding of TB therapies.
Skills the Lab Values
genomic sequencingCRISPR interferencemetabolomicsbiochemical techniquesanimal model experimentationdata analysisclinical trial designin vitro assaysgene knockout techniques
Output against the department
Publications207top 31% of dept.150th of 486
this lab
most publishedleast published
Citations16ktop 24% of dept.115th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.