University of Illinois Chicago · PharmacologyAcute Lung Injury Research Lab
Dolly Mehta · Chicago, Illinois
Research Focus
Dr. Dolly Mehta's lab at the University of Illinois at Chicago focuses on understanding and treating acute lung injuries, which are often caused by infections. The research examines how certain cells in the lungs, particularly macrophages and endothelial cells, behave during inflammation and injury. By studying these cells' mechanisms, the lab aims to develop targeted therapies that protect lung function and promote healing during acute respiratory distress syndrome.
acute lung injurymacrophage plasticityendothelial cellsTRPC6inflammationacute respiratory distress syndromecell therapyimmunologysignal transduction
Research Aims
4AIM 01Identify the molecular mechanisms of TRPC6 in endothelial cells during lung injuries.
AIM 02Explore the role of macrophage plasticity in promoting lung repair after injury.
AIM 03Investigate how endothelial cells influence macrophage function in the lungs.
AIM 04Develop novel therapeutic strategies targeting TRPC6 to improve outcomes in acute lung injury.
Skills the Lab Values
cell culturemouse modelsRNA sequencingimmunohistochemistryflow cytometrymolecular cloningWestern blotin vivo imaginggenomic analysis
Output against the department
Publications195top 45% of dept.207th of 462
this lab
most publishedleast published
Citations10ktop 37% of dept.172nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.