Dartmouth College · EngineeringThe Antibody Nexus
Margaret E Ackerman · Hanover, New Hampshire
Research Focus
Dr. Margaret E Ackerman's lab at Dartmouth College focuses on novel antibody therapies to combat viral infections, specifically HIV and neonatal herpes simplex virus (nHSV). They explore how broadly neutralizing antibodies (bNAbs) can be engineered and optimized to enhance their effectiveness in preventing these infections. The research aims to translate these approaches into practical treatments that can significantly improve health outcomes for affected populations.
HIVbroadly neutralizing antibodiesneonatal herpes simplex virusantibody engineeringimmunity
Research Aims
5AIM 01Investigate how Fc engineering can enhance the antiviral activity of broadly neutralizing antibodies.
AIM 02Evaluate the effectiveness of antibody combinations to improve neutralization against HIV.
AIM 03Define mechanisms of action for therapeutic antibodies in preventing neonatal herpes simplex virus infections.
AIM 04Understand the role of viral Fc receptors in modulating antibody efficacy.
AIM 05Develop strategies for optimizing maternal antibody transfer to protect newborns against viral infections.
Skills the Lab Values
antibody engineeringanimal modelsin vivo experimentationcell cultureimmunological assays
Output against the department
Publications302top 28% of dept.78th of 278
this lab
most publishedleast published
Citations9.4ktop 39% of dept.108th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.