University of Illinois Chicago · PharmacologyThe Calcification Lab
Shilpa Sant · Chicago, Illinois
Research Focus
Dr. Shilpa Sant's lab focuses on understanding how specific components within the breast cancer microenvironment can influence tumor growth and metastasis. By using engineered mineralized hydrogels that mimic the soft tissue environment of the breast, the research aims to explore the role of microcalcifications in the development and progression of breast cancer. The findings may help identify new treatment strategies and biomarkers that could improve patient outcomes.
breast cancermicrocalcificationstumor microenvironmentmetastasisextra-cellular matrix hydrogels
Research Aims
4AIM 01Investigate how malignant microcalcifications influence tumor growth and bone mimicry in breast cancer.
AIM 02Examine the role of breast cancer cell interactions with microcalcifications in promoting metastasis to bone.
AIM 03Identify novel biomarkers associated with microcalcification and tumor progression.
AIM 04Develop local therapeutic interventions to mitigate metastatic spread in high-risk patients.
Skills the Lab Values
in vitro culturehydrogel engineeringmolecular biology techniquesimmunohistochemistryanimal models (CDX and PDX)
Output against the department
Publications97bottom 24% of dept.350th of 462
this lab
most publishedleast published
Citations8.3ktop 45% of dept.207th of 462
this lab
most citedleast cited
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