University of North Carolina at Charlotte · BiologyTomida DNA Lab
Junya Tomida · Charlotte, North Carolina
Research Focus
Dr. Junya Tomida's research lab focuses on understanding the complex interactions between the DNA repair factor REV7 and the tumor suppressor protein p53, which plays a key role in preventing cancer. The lab studies how REV7 regulates p53 protein levels and activity, especially in the context of various DNA damage conditions. By uncovering the mechanisms behind these interactions, the lab aims to identify new insights into cancer development and potential therapeutic targets.
DNA repairtumor suppressorp53 signalingREV7cancer researchgenome stabilityprotein regulation
Research Aims
4AIM 01Determine how REV7 regulates p53 protein destabilization.
AIM 02Investigate how REV7 influences p53 activity.
AIM 03Establish the role of REV7 in cell cycle control and apoptosis.
AIM 04Identify mechanisms of p53 regulation under DNA damage conditions.
Skills the Lab Values
biochemical techniquesmolecular cloningCRISPR genome editingcell culture and maintenanceWestern blottingRNA extraction and analysisflow cytometrydata analysis using Python
Output against the department
Publications68bottom 18% of dept.845th of 1,033
this lab
most publishedleast published
Citations1.7kbottom 11% of dept.920th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.