University of Utah · BiologyImmunological Memory and B Cell Dynamics Lab
Koushik Roy · Salt Lake City, Utah
Research Focus
Dr. Koushik Roy's lab focuses on understanding how certain proteins control the development of immune cells that produce antibodies, specifically targeting the processes that help create long-lasting immunity. In particular, the lab studies how different signaling pathways affect the formation of memory B cells and plasma cells, which are critical for responding to infections and vaccines. The research aims to uncover mechanisms that could lead to improved vaccines and therapies for better immune responses.
humoral immunityB cell differentiationplasma cellsmemory B cellsNF-kB signalingvaccine responseantibodiesimmunologytranscription factorsaffinity maturation
Research Aims
3AIM 01Define how IkBa and IkBe regulate affinity maturation and the generation of PCs and MBCs.
AIM 02Identify how cell surface receptors regulate the abundance of IkBa and IkBe and control activation in GC B cells.
AIM 03Determine the effects of IkBa-deficient and IkBe-deficient mice on humoral immunity against influenza.
Skills the Lab Values
cell cultureflow cytometryWestern blotuse of knockout micegene expression analysisenzyme-linked immunosorbent assay (ELISA)fluorescence microscopyPCRimmunofluorescencein vivo immunology techniques
Output against the department
Publications87bottom 28% of dept.739th of 1,033
this lab
most publishedleast published
Citations2.5kbottom 18% of dept.851st of 1,033
this lab
most citedleast cited
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