University of Pennsylvania · BiologyCARdinal Innovations Lab
Carl H. June · Philadelphia, Pennsylvania
Research Focus
Dr. Carl H. June's lab at the University of Pennsylvania focuses on developing advanced immunotherapies for blood cancers, particularly through the use of chimeric antigen receptor (CAR) T cell therapies. Their innovative research aims to extend these therapies beyond current limits by combining CAR T cells with genetic editing techniques. The lab works on a range of hematologic malignancies, including multiple myeloma and acute myeloid leukemia, aiming to transform the treatment landscape for these challenging diseases.
CAR T therapyhematologic malignanciesgenome editingCRISPRimmunotherapyacute myeloid leukemiamultiple myelomaclinical trialschronic lymphocytic leukemiagene modification
Research Aims
5AIM 01Develop next-generation CAR T cell therapies for various blood cancers.
AIM 02Translate CAR T cell research into effective treatments for patients.
AIM 03Investigate the impact of genetic modifications on CAR T cell efficacy.
AIM 04Explore combination therapies to enhance CAR T cell persistence and function.
AIM 05Address unmet medical needs in hematologic malignancies through innovative research.
Skills the Lab Values
cell cultureCAR T cell engineeringgenomic editing (CRISPR)clinical trial designbiostatisticsflow cytometrygene therapy techniquesmolecular biology techniquescellular immunologyanalytical techniques for immune response
Output against the department
Publications1,420top 1% of dept.6th of 1,033
this lab
most publishedleast published
Citations147ktop 1% of dept.5th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.