University of Virginia-Main Campus · PhysiologyProtein Quality Control Lab
Ling Qi · Charlottesville, Virginia
Research Focus
Dr. Ling Qi's lab at the University of Virginia focuses on the role of a protein complex known as SEL1L-HRD1 in various health-related processes. The lab investigates how this complex helps to degrade misfolded proteins in our cells, affecting conditions such as Alzheimer's disease and liver diseases. Their work sheds light on how genetic mutations may disrupt this important degradation pathway and contribute to disease.
ERADSEL1L-HRD1bile acid metabolismAlzheimer's diseaseprotein quality controlneuroinflammationmouse modelsmetabolic diseasescholestatic liver diseasegenetic mutations
Research Aims
3AIM 01Identify the disease-causing mutations in SEL1L and SYVN1 in human patients.
AIM 02Examine the role of SEL1L-HRD1 ERAD in bile acid metabolism and liver injury.
AIM 03Investigate the interaction between STING and SEL1L-HRD1 ERAD in Alzheimer's disease pathogenesis.
Skills the Lab Values
mouse modelsprotein purificationcell cultureWestern blotimmunohistochemistryCRISPRgenotypingRNA isolationquantitative PCRtransfection techniques
Output against the department
Publications268top 20% of dept.57th of 286
this lab
most publishedleast published
Citations13ktop 22% of dept.64th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.