University of Virginia-Main Campus · PharmacologyLeitinger Lab
Norbert Leitinger · Charlottesville, Virginia
Research Focus
Dr. Norbert Leitinger's lab at the University of Virginia focuses on understanding how metabolic processes influence inflammation, particularly through the enzyme Acetyl CoA Carboxylase (ACC). The research aims to uncover how ACC affects immune cell function during inflammation and how metabolic dysregulation can lead to improper immune responses, especially in individuals with obesity and diabetes. By exploring the connection between lipid metabolism and inflammation, the lab seeks to identify new therapeutic targets for managing inflammatory diseases.
inflammationmetabolismAcetyl CoA Carboxylasemacrophagesimmune responselipid biosynthesisdiabetesobesityinnate immunitytranscriptional regulation
Research Aims
2AIM 01Investigate how ACC activity influences the induction and resolution of the acute inflammatory response in mice.
AIM 02Explore the transcriptional and metabolic mechanisms that are regulated by ACC during inflammation.
Skills the Lab Values
animal modelsmacrophage culturegenetic knockout techniquespharmacological assaysgene expression analysishistone acetylation assaysATAC-seqmetabolic profilingclinical trial protocolsproteomics
Output against the department
Publications217top 39% of dept.179th of 462
this lab
most publishedleast published
Citations16ktop 24% of dept.109th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.