Princeton University · BiochemistryThe RNA Localization Lab
Elizabeth R Gavis · Princeton, New Jersey
Research Focus
Elizabeth Gavis's lab at Princeton University studies how messenger RNAs (mRNAs) are controlled during the development of fruit flies (Drosophila). They focus on understanding how mRNAs are localized and regulated to ensure that proteins are produced in the right place and at the right time during embryonic development. Their research has implications for understanding diseases such as cancer and neurodegenerative disorders, as the rules governing mRNA behavior can reveal why these processes go wrong in various health issues.
mRNA localizationtranslational controlDrosophilagerm granulespost-transcriptional regulationembryonic developmentRNA metabolismgene expressionprotein distribution
Research Aims
5AIM 01Investigate how mRNAs are localized in Drosophila embryos.
AIM 02Determine the role of germ granules in RNA regulation.
AIM 03Examine how mRNAs are translated at specific cellular locations.
AIM 04Explore the self-organization mechanisms of mRNA in RNA granules.
AIM 05Understand the connection between mRNA regulation and developmental disorders.
Skills the Lab Values
microscopybiochemical assaysgenetic manipulationRNA analysisbiological modelinghigh resolution imagingdata analysiscell cultureDrosophila genetics
Output against the department
Publications116bottom 31% of dept.279th of 402
this lab
most publishedleast published
Citations6.3kbottom 36% of dept.258th of 402
this lab
most citedleast cited
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