Indiana University-Purdue University-Indianapolis · GeneticsThe Microglia Project
Bruce T Lamb · Indianapolis, Indiana
Research Focus
Dr. Bruce T. Lamb's lab focuses on understanding how genetic variations in the PLCG2 gene influence the biology of microglia, the immune cells of the brain, and contribute to Alzheimer's disease. By studying these variants in mouse models, the lab aims to elucidate their effects on disease progression and identify potential therapeutic targets. This research is crucial for developing new treatments for Alzheimer's disease.
Alzheimer's DiseaseMicrogliaGeneticsPLCG2Neurodegenerative DiseasesInnate Immune ResponseRodent ModelsDisease PathogenesisGenetic Variants
Research Aims
3AIM 01Determine the impact of PLCG2 variants on Alzheimer's disease-related phenotypes in rodent models.
AIM 02Identify molecular pathways altered by PLCG2 variants in microglia.
AIM 03Evaluate how PLCG2 variants affect intracellular signaling in microglia.
Skills the Lab Values
Mouse ModelsGene EditingRNA ExtractionPCRWestern BlottingImmunohistochemistryFlow CytometryData Analysis in RCell Culture
Output against the department
Publications287top 29% of dept.74th of 259
this lab
most publishedleast published
Citations17ktop 35% of dept.90th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.