Columbia University in the City of New York · BiochemistryMicrobial Genomics and Evolution Lab
Laura F Landweber · New York, New York
Research Focus
Dr. Laura F Landweber's lab at Columbia University focuses on understanding how natural processes in tiny organisms called microbial eukaryotes, like Oxytricha, edit their genomes. They explore complex ways DNA and RNA are processed and rearranged, shedding light on genetic diversity and evolution. This research is important because it can reveal insights into genetic disorders and cancers seen in humans.
genome editingRNA biologyOxytrichagenome stabilityevolutionnoncoding RNAsgenome rearrangementsmolecular genetics
Research Aims
5AIM 01Investigate the molecular mechanisms of genome editing in Oxytricha.
AIM 02Examine the role of DNA N6-adenine methylation during genome rearrangement.
AIM 03Analyze the interactions between noncoding RNAs and RNA-binding proteins in genome remodeling.
AIM 04Explore the evolutionary origins of complex genetic architectures in microbial eukaryotes.
AIM 05Assess how genome instability contributes to human diseases.
Skills the Lab Values
molecular cloningRNA sequencingPCRgenomic editingcell culturecomparative genomicschromatin biochemistrybioinformaticssmall and long noncoding RNA analysis
Output against the department
Publications218top 36% of dept.146th of 402
this lab
most publishedleast published
Citations7.2kbottom 39% of dept.245th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.