WMCWeill Medical College of Cornell University · Microbiology & Immunology
Ma Oncogenomics Lab
Xiaojing Ma · New York, New York
Research Focus
Dr. Xiaojing Ma's research lab at Weill Medical College focuses on understanding the role of a gene called UBR5 in cancer, particularly breast and ovarian cancer. By studying how UBR5 affects tumor growth and immune response, the lab aims to uncover new therapeutic strategies that could help treat aggressive types of breast cancer that resist current treatments. The findings from this research could significantly improve patient outcomes by targeting specific biological processes that drive cancer progression.
UBR5breast cancertumorigenesisimmunoregulationchemokinesE3 ubiquitin ligasePD-L1tumor microenvironmenttriple-negative breast cancertherapeutic strategies
Research Aims
5AIM 01Characterize how UBR5 regulates CDC73 protein turnover and its effects on immune cell recruitment.
AIM 02Investigate the mechanisms by which UBR5 enhances IFN-g-activated signaling independently of E3 ligase activity.
AIM 03Explore therapeutic potentials of inhibiting UBR5 in aggressive breast cancer.
AIM 04Identify critical signaling pathways regulated by UBR5 that contribute to tumor growth and metastasis.
AIM 05Develop novel interventions targeting UBR5 and its pathways to improve treatment outcomes.
Skills the Lab Values
cell culturemouse modelsPCRWestern blotflow cytometryRNA sequencingbiochemical assayssignal transduction analysisprotein purificationgene editing techniques
Output against the department
Publications199top 32% of dept.157th of 486
this lab
most publishedleast published
Citations12ktop 30% of dept.147th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.