University of California-Santa Cruz · EngineeringCancer Isoform Discovery Lab
Angela Norie Brooks · Santa Cruz, California
Research Focus
Dr. Angela Norie Brooks' lab at the University of California Santa Cruz focuses on understanding how different isoforms of cancer genes contribute to tumor growth and treatment resistance. The lab uses advanced sequencing techniques to analyze RNA from cancer cells and tumors, aiming to uncover vital mutations that can inform personalized cancer therapies. By doing so, the research hopes to improve cancer treatments and responses to drugs.
cancer genomicsisoform-specific functiondrug resistanceRNA sequencingpersonalized medicine
Research Aims
3AIM 01Generate a compendium of human pan-cancer gene isoform variants using long-read sequencing.
AIM 02Identify gene isoform variants linked to resistance against targeted cancer therapies.
AIM 03Characterize the functional impact of isoforms on cancer development and treatment response.
Skills the Lab Values
long-read transcriptome sequencingcell cultureXenograft modelsin vitro functional assaysRNA processingcancer cell line analysisbioinformaticsdata analysismolecular cloning
Output against the department
Publications183bottom 47% of dept.146th of 278
this lab
most publishedleast published
Citations37ktop 7% of dept.19th of 278
this lab
most citedleast cited
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