University of California-San Francisco · BiologyImmune Dynamics and Therapy Lab
Matthew F Krummel · San Francisco, California
Research Focus
Dr. Matthew Krummel's lab at UCSF focuses on understanding how the immune system distinguishes between self and foreign cells. Through innovative research on immune cells like T cells and dendritic cells, the lab aims to improve treatments for cancer and autoimmune diseases. They explore specific cellular mechanisms that could enhance the effectiveness of immunotherapies, ultimately aiming to boost the body's ability to fight tumors while minimizing autoimmunity.
immune systemT cellsdendritic cellsimmunotherapytumor microenvironmentautoimmunitycellular signalingcell engineeringSASOspatial transcriptomics
Research Aims
5AIM 01Investigate how the immune system recognizes self versus foreign cells.
AIM 02Explore the function of the Self-Associated Storage Organelle (SASO) in immune education.
AIM 03Study the interplay between T cell receptors and their membrane environments.
AIM 04Examine how to enhance the tumor microenvironment to activate immune cells against cancer.
AIM 05Design strategies to improve T cell therapies for better cancer treatment.
Skills the Lab Values
cell cultureflow cytometryimmunoassayselectron microscopyCRISPRmass spectrometry3D imaginggenetic screeningmicroscopydata analysis
Output against the department
Publications369top 13% of dept.137th of 1,033
this lab
most publishedleast published
Citations42ktop 7% of dept.68th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.