Boston University · PharmacologyFeng Lab
Hui Feng · Boston, Massachusetts
Research Focus
Dr. Hui Feng's lab studies neuroblastoma, a type of cancer that affects children, particularly focusing on how certain proteins influence immune responses in tumors. They investigate how MYCN, a gene often associated with cancer aggressiveness, contributes to a hostile tumor microenvironment that suppresses the immune system. By understanding these mechanisms, the team aims to develop better immunotherapy strategies to fight neuroblastoma and possibly other cancers.
neuroblastomaMYCNimmunosuppressiontumor microenvironmentCKLF1
Research Aims
3AIM 01Characterize the immune cells recruited by CKLF1 in neuroblastoma.
AIM 02Elucidate how CKLF1 influences CD4+ T cells to induce immunosuppression.
AIM 03Investigate the effects of inhibiting CKLF1 on enhancing immunotherapy effectiveness.
Skills the Lab Values
zebrafish model systemsimmunohistochemistryflow cytometrycell culture techniquessingle-cell transcriptomics
Output against the department
Publications278top 28% of dept.128th of 462
this lab
most publishedleast published
Citations12ktop 32% of dept.150th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.