University of Nebraska Medical Center · BiologyNg Lab
Caroline L Ng · Omaha, Nebraska
Research Focus
Dr. Caroline L Ng's lab studies malaria, particularly the mechanisms behind resistance to artemisinin, a key treatment for this disease. They investigate how the proteasome, a protein degradation system, affects the survival of malaria parasites under drug pressure. By understanding these processes at a molecular level, the lab aims to develop new therapeutic strategies to combat artemisinin-resistant malaria and improve treatment outcomes.
malariaartemisinin resistanceproteostasisPlasmodium falciparumproteasome inhibitorsubiquitinationunfolded protein responseantimalarialsdrug resistance
Research Aims
3AIM 01Examine the role of the proteasome in artemisinin resistance.
AIM 02Investigate the impact of ubiquitination patterns on malaria parasite survival.
AIM 03Analyze the dysregulation of the ubiquitin-proteasome system in relation to drug resistance.
Skills the Lab Values
molecular cloningcell cultureparasite genotypingWestern blottingdrug susceptibility assaysprotein purificationfluorescence microscopyCRISPR gene editingbioinformatics
Output against the department
Publications38bottom 6% of dept.963rd of 1,033
this lab
most publishedleast published
Citations2.0kbottom 14% of dept.887th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.