Stony Brook University · Microbiology & ImmunologyIntestinal Immunity and Memory T Cell Unit
Brian S Sheridan · Stony Brook, New York
Research Focus
Dr. Brian Sheridan's lab focuses on understanding how priming affects the development of a specific type of immune cell called tissue-resident memory T cells in the intestine. Their research aims to uncover the mechanisms by which dietary factors, like vitamin A, influence the formation of these cells during immune responses. The ultimate goal is to improve vaccine strategies for gastrointestinal infections and to address issues related to vitamin A deficiency in populations with poor immune responses.
T cell developmentintestinal immunityvitamin Amemory T cellsvaccine design
Research Aims
3AIM 01Investigate how priming in mesenteric lymph nodes affects the differentiation of intestinal CD8 memory T cells.
AIM 02Determine the role of retinoic acid in the development of intestinal CD8 memory T cells.
AIM 03Assess how dietary vitamin A impacts vaccine efficacy by modulating memory T cell development.
Skills the Lab Values
cell culturemouse modelsimmunological assaysflow cytometryPCRdietary supplementation in animal studies
Output against the department
Publications101bottom 36% of dept.308th of 486
this lab
most publishedleast published
Citations3.2kbottom 23% of dept.372nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.