RURush University · Microbiology & Immunology
Wallace Neuroinflammation Lab
Jennillee Wallace · Chicago, Illinois
Research Focus
Dr. Jennillee Wallace's lab at Rush University Medical Center studies how HIV affects the brain, specifically looking at its impact on cognitive functions and inflammation. By using human-mouse chimera models, the lab investigates how HIV-infected immune cells infiltrate the brain and contribute to cognitive deficits. This research aims to deepen our understanding of neuroHIV, especially in individuals undergoing antiretroviral therapy.
HIVneuroinflammationneurocognitive deficitschimera modelantiretroviral therapycognitive impairmentbrain immune interactionsin vivo modelingHIV-associated neurocognitive disorder
Research Aims
5AIM 01Develop a human-mouse chimera model to study HIV interactions in the brain.
AIM 02Investigate the role of immune cells in the development of neuroHIV.
AIM 03Examine the contribution of antiretroviral therapy on brain health in HIV-infected individuals.
AIM 04Assess the effects of HIV-induced neuroinflammation on cognitive functions.
AIM 05Clarify how brain and peripheral immune cell interactions define neurocognitive deficits in HIV.
Skills the Lab Values
in vivo modelinganimal handlingT cell assaysHIV biologyimmunohistochemistryRNA extractioncell culture techniquesflow cytometryWestern blotting
Output against the department
Publications19bottom 3% of dept.469th of 486
this lab
most publishedleast published
Citations507bottom 3% of dept.470th of 486
this lab
most citedleast cited
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