WMCWeill Medical College of Cornell University · Biology
Moscat Cancer Lab
Jorge Moscat · New York, New York
Research Focus
Dr. Jorge Moscat's lab focuses on understanding the mechanisms of mesenchymal colorectal cancer (CRC), a highly aggressive type of cancer with poor outcomes and limited treatment options. They aim to uncover how cholesterol metabolism contributes to the development of this cancer and how specific proteins can regulate this process. The lab combines mouse models and human data to identify new potential therapies for CRC, which may help overcome its challenges in treatment.
cholesterol metabolismcolorectal cancermesenchymal CRCtumorigenesisprotein kinase regulationSREBP2therapeutic targetsdesmoplastic stroma
Research Aims
5AIM 01Determine the role of increased cholesterol metabolism in mesenchymal CRC initiation and progression.
AIM 02Evaluate the impact of a high-cholesterol diet on tumor progression in mesenchymal CRC.
AIM 03Investigate how PKC/iota regulates cholesterol biosynthesis in CRC.
AIM 04Analyze the phosphorylation effects of PKC/iota on SCAP in vitro.
AIM 05Assess the functional role of SCAP phosphorylation in CRC tumorigenesis in vivo.
Skills the Lab Values
mouse modelscholesterol biosynthesis assessmentdiet modification experimentscell cultureWestern blotRNA sequencingtranscriptional analysismetabolic tracingphosphorylation assaysdata analysis
Output against the department
Publications283top 21% of dept.211th of 1,033
this lab
most publishedleast published
Citations37ktop 8% of dept.83rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.