Northwestern University · BiochemistryShilatifard Epigenetics Lab
Ali Shilatifard · Evanston, Illinois
Research Focus
Dr. Ali Shilatifard's lab focuses on understanding how mutations in chromatin modifiers like MLL4 contribute to cancer, especially bladder cancer. His research combines biochemical studies with pre-clinical trials to explore how these mutations can inform targeted therapies and improve patient treatment options. By studying specific mutations and their effects, the lab aims to develop biomarkers for better cancer diagnostics and treatment strategies.
chromatin modificationbladder cancerepigeneticscancer therapybiomarkersgene expressionmutation analysispreclinical modelstherapeutics development
Research Aims
3AIM 01Define how MLL4 truncation mutations alter its function in bladder cancer.
AIM 02Develop biomarkers based on MLL4 localization and mutation status for patient stratification.
AIM 03Evaluate the effectiveness of pemetrexed treatment in MLL4-mutated bladder cancer.
Skills the Lab Values
cell cultureChIP-seqRNA sequencingmass spectrometryimmunohistochemistrymouse modelsbiochemical assaysprotein purificationbioinformaticsmolecular cloning
Output against the department
Publications426top 11% of dept.45th of 402
this lab
most publishedleast published
Citations50ktop 4% of dept.18th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.