Baylor College of Medicine · BiologyGarcia Genetics Lab
Thomas Garcia · Houston, Texas
Research Focus
Dr. Thomas Garcia's lab at Baylor College of Medicine is focused on understanding the genetic causes of male infertility, which is not well understood currently. The research involves using advanced sequencing techniques to identify new genes that influence male fertility. By studying both blood and sperm samples and validating findings in mouse models, the lab aims to shed light on the genetics of infertility and potentially identify targets for new male contraceptive solutions.
male infertilitygeneticssequencingCRISPRsperm developmenthormonal contraceptivesgene validation
Research Aims
5AIM 01Identify novel genes linked to male infertility through advanced sequencing technology.
AIM 02Validate the function of these genes using CRISPR/Cas9 in mouse models.
AIM 03Explore the molecular mechanisms underlying male fertility and infertility.
AIM 04Assess the potential of newly identified genes as targets for male contraception.
AIM 05Demonstrate how specific mutations affect sperm development.
Skills the Lab Values
long-read sequencingCRISPR/Cas9mouse modelsbioinformaticsgenomic analysissperm and blood sample processingmutation analysisphenotype assessmentmolecular biology techniques
Output against the department
Publications56bottom 14% of dept.889th of 1,033
this lab
most publishedleast published
Citations1.4kbottom 8% of dept.947th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.