University of Florida · PharmacologyBurris Mimetics Lab
Thomas P Burris · Gainesville, Florida
Research Focus
The lab of Dr. Thomas P Burris focuses on developing new treatments for dementia and Alzheimer's disease using synthetic compounds that mimic the effects of exercise. By targeting specific nuclear receptors in the brain, these compounds aim to enhance cognitive function and reduce the characteristic amyloid plaques associated with Alzheimer's. The research is significant as it addresses a growing public health concern with over five million Americans affected by Alzheimer's disease.
exercise mimeticsAlzheimer's diseasedementiacognitive functionamyloid betanuclear receptorspharmacotherapyagingcognitive enhancementoxidative metabolism
Research Aims
5AIM 01Develop optimized ERR agonists to treat Alzheimer's disease.
AIM 02Investigate the role of ERR receptors in cognitive function.
AIM 03Evaluate the efficacy of synthetic compounds in animal models of dementia.
AIM 04Assess the impact of treatment on amyloid plaque formation.
AIM 05Explore potential applications of ERR agonists in other neurodegenerative conditions.
Skills the Lab Values
cell cultureanimal modelspharmacological assayscompound synthesisWestern blotRNA sequencingimmunohistochemistrybehavioral testing in micedata analysis using Pythonbiochemical assays
Output against the department
Publications273top 29% of dept.132nd of 462
this lab
most publishedleast published
Citations18ktop 21% of dept.97th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.