Harvard University · BiologySabatini Neurotransmission Lab
Bernardo L Sabatini · Cambridge, Massachusetts
Research Focus
Dr. Bernardo L. Sabatini's lab focuses on understanding how the brain's neurotransmitter signals, especially dopamine, influence decision-making and behavior. The research investigates how different types of dopamine signaling operate, impacting learning and memory, as well as exploring the complexities of synaptic transmission in the brain. By studying these processes in mice, the lab aims to uncover mechanisms related to neuropsychiatric diseases and improve our understanding of brain function.
dopamineneurotransmissionsynaptic functionlearningneuropsychiatric disordersdecision makingneuromodulationmouse modelsbehavioral neuroscienceGABA
Research Aims
5AIM 01Investigate the role of tonic dopamine in decision-making processes.
AIM 02Examine the interaction between different neurotransmitters and their effects on behavior.
AIM 03Explore the mechanisms behind synaptic transmission in various neuronal populations.
AIM 04Identify unique properties of neurons that contribute to brain function.
AIM 05Understand how disturbances in neurotransmitter communication are linked to neurological diseases.
Skills the Lab Values
real-time dopamine measurementin vivo animal behavior experimentscell culture techniqueshistological methodsintracranial injectionsoptogeneticsfluorescence imaginggenetic manipulation in miceelectrophysiologymicroscopy
Output against the department
Publications309top 18% of dept.183rd of 1,033
this lab
most publishedleast published
Citations36ktop 8% of dept.84th of 1,033
this lab
most citedleast cited
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