Indiana University-Purdue University-Indianapolis · Biomedical EngineeringTerrito Neuroinflammation Lab
Paul Richard Territo · Indianapolis, Indiana
Research Focus
Dr. Paul Territo's research lab at Indiana University focuses on understanding neuroinflammation in Alzheimer's disease and related dementias. The lab studies P2X7 receptors, which play a significant role in communication between brain cells and are involved in the inflammatory processes that lead to neurodegeneration. By investigating these mechanisms using advanced mouse models, the lab aims to develop potential treatments to prevent cognitive decline associated with these diseases.
P2X7 receptorsneuroinflammationAlzheimer's diseasedementiamicroglial activationcytokinesmouse modelspharmacologyPET imagingprotein expression
Research Aims
3AIM 01Characterize mouse models to study P2X7 receptor activity in neurodegeneration.
AIM 02Assess the effect of P2X7 receptor inhibition on neuroinflammation and neuronal health.
AIM 03Develop a dosing strategy for an antagonist to modulate P2X7 receptor signaling in mouse models.
Skills the Lab Values
mouse modelsPET/CT imagingbiochemical assaysmolecular analysisimmunopathologyMALDI-IMSgene targetingbehavioral testingdata analysispharmacokinetics
Output against the department
Publications266top 37% of dept.217th of 595
this lab
most publishedleast published
Citations3.9kbottom 30% of dept.417th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.