University of Michigan-Ann Arbor · NeuroscienceEpilepsy and mTORopathy Research Group
Yu Wang · Ann Arbor, Michigan
Research Focus
Dr. Yu Wang's lab at the University of Michigan focuses on understanding epilepsy associated with mTORopathies, particularly in how these conditions develop and progress. They use advanced techniques to explore the cellular and molecular changes in the brain that lead to epilepsy, especially in children with drug-resistant forms of the disease. The lab combines animal models with human tissue studies to investigate potential therapeutic strategies and improve seizure outcomes.
epileptogenesismTORopathiesfocal cortical dysplasiaepilepsycomplement C3electrophysiologyRNA sequencinganimal modelsneuroinflammation
Research Aims
5AIM 01Investigate the cellular mechanisms underlying epileptogenesis in mTORopathies.
AIM 02Examine the role of complement component C3 in neuronal injury and excitatory/inhibitory balance.
AIM 03Explore molecular profiling of dysplastic cortex using human and animal models.
AIM 04Assess therapeutic potential of targeting C3 to modify disease progression.
AIM 05Determine how specific cellular pathways contribute to the development of drug-resistant epilepsy.
Skills the Lab Values
animal modelselectrophysiologyRNA sequencingmolecular geneticstransgenicscell cultureWestern blotimmunohistochemistrydata analysisexperimental design
Output against the department
Publications842top 5% of dept.33rd of 671
this lab
most publishedleast published
Citations46ktop 8% of dept.52nd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.