Harvard University · BiologyHuman Skeletal Genetics Lab
Terence D Capellini · Cambridge, Massachusetts
Research Focus
Dr. Terence D Capellini's lab at Harvard University focuses on studying the genes that determine the unique features of the human skeleton compared to other mammals, particularly mice. By examining the human fetal skeleton, the lab uses advanced genomic techniques to find causal genetic variants linked to skeletal diseases. Their work aims to enhance our understanding of musculoskeletal development, which can lead to better insights into conditions like hip dysplasia and osteoarthritis.
musculoskeletal developmenthuman geneticssingle cell multiomicsspatial transcriptomicsskeletal diseasesgenomic researchhigh-throughput assaysdisease variantsgene expression
Research Aims
3AIM 01Identify genes and regulatory regions affecting skeletal morphology in humans.
AIM 02Map the transcriptome and epigenome of human joint tissues using single cell techniques.
AIM 03Determine the effects of genetic variants on gene expression using high-throughput assays.
Skills the Lab Values
single cell multiomicsspatial transcriptomicsgenomic data analysishigh-throughput reporter assayscell culturetissue harvestingtranscriptome mappingepigenomic profilingbioinformatics
Output against the department
Publications135bottom 48% of dept.531st of 1,033
this lab
most publishedleast published
Citations3.3kbottom 25% of dept.777th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.