Michigan State University · NeuroscienceSteece-Collier Lab
Kathy Steece-Collier · East Lansing, Michigan
Research Focus
Dr. Kathy Steece-Collier's lab focuses on developing gene therapy techniques to treat levodopa-induced dyskinesia (LID), a painful side effect of Parkinson's disease medications. The lab investigates how silencing specific calcium channels in the brain can help prevent or reverse LID, especially in older patients and those with varying onset ages. Ultimately, the goal is to improve the quality of life for people living with Parkinson’s disease by exploring new therapeutic options for LID.
Parkinson's diseaselevodopa-induced dyskinesiagene therapycalcium channelsCaV1.3neuroprotectionagingsex differencesnonhuman primatesadeno-associated virus
Research Aims
5AIM 01Investigate the role of CaV1.3 calcium channels in levodopa-induced dyskinesia.
AIM 02Evaluate the effectiveness of gene therapy in preventing LID in aging parkinsonian models.
AIM 03Examine sex-related differences in response to CaV1.3 silencing.
AIM 04Determine the ability of CaV1.3 silencing to reverse established LID.
AIM 05Explore therapeutic options for both idiopathic and young onset Parkinson's disease.
Skills the Lab Values
RNA interferenceanimal models of diseasegene deliverymotor function assessmentbehavioral analysisimmunohistochemistryWestern blottingdata analysisbiostatisticsanimal handling
Output against the department
Publications83bottom 24% of dept.505th of 671
this lab
most publishedleast published
Citations4.1kbottom 31% of dept.465th of 671
this lab
most citedleast cited
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