Rutgers University-New Brunswick · PharmacologyCalcium Metabolis Lab
Paula Bartlett · New Brunswick, New Jersey
Research Focus
Dr. Paula Bartlett's lab focuses on understanding how high fat diets disrupt calcium signaling in the liver, which is crucial for regulating metabolism. The research is primarily centered on non-alcoholic fatty liver disease (NAFLD) and its links to insulin resistance and type 2 diabetes. By uncovering the molecular mechanisms and the effects of diet-induced changes, the lab aims to find potential solutions for managing these common health issues.
calcium signalingnon-alcoholic fatty liver diseaseinsulin resistancehigh fat dietmetabolismhormonal regulationdiabeteshepatocyteslipogenesis
Research Aims
3AIM 01Identify the molecular mechanisms by which high fat diet suppresses calcium signaling.
AIM 02Investigate zonal differences in calcium signaling in the liver affected by high fat diet.
AIM 03Test how high fat diet affects the zonal regulation of lipid metabolism and promotes pericentral lipogenesis.
Skills the Lab Values
cell culturemolecular biology techniquesRNA extractionWestern blottingimmunohistochemistryin vivo studies in micehepatic perfusion techniquesmetabolic profilingdata analysis using statistical software
Output against the department
Publications29bottom 2% of dept.451st of 462
this lab
most publishedleast published
Citations739bottom 3% of dept.450th of 462
this lab
most citedleast cited
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