Duke University · BiologyHuang Oncology Lab
Jiaoti Huang · Durham, North Carolina
Research Focus
Dr. Jiaoti Huang's lab at Duke University focuses on understanding the complex mechanisms behind prostate cancer progression, particularly two aspects: the role of alternative polyadenylation in cancer development and the targeting of hard-to-reach transcription factors to hinder metastasis. The lab aims to uncover how specific genetic and molecular changes fuel prostate cancer's progression to more aggressive forms and develop innovative therapeutic strategies to improve patient outcomes.
prostate canceralternative polyadenylationmetastasisHoxB13gene therapyRNA targetingCRISPRnanoparticlesoncogenes
Research Aims
3AIM 01Identify alternative polyadenylation target genes in prostate cancer progression using clinical samples and cell models.
AIM 02Develop a computational model to infer upstream regulators of alternative polyadenylation.
AIM 03Characterize molecular regulation of identified alternative polyadenylation regulators and their biological functions.
Skills the Lab Values
CRISPRRNA sequencingnanoparticle designcell culturebioinformaticsmolecular cloninganimal modelsgene expression analysislipid nanoparticle delivery
Output against the department
Publications728top 3% of dept.31st of 1,033
this lab
most publishedleast published
Citations27ktop 14% of dept.142nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.