WMCWeill Medical College of Cornell University · Neuroscience
Burre Synuclein Lab
Jacqueline Burre · New York, New York
Research Focus
Dr. Jacqueline Burre's lab focuses on understanding the roles of different types of synuclein proteins in the brain and their connection to neurodegenerative diseases like Parkinson’s disease and Alzheimer’s disease. Her team is investigating how these proteins affect nerve cell functions and how disruptions in their behavior might lead to early signs of these diseases. By using specialized mouse models and biochemical techniques, the lab aims to identify potential early biomarkers and novel therapies for these age-related conditions.
synucleinsynaptic functionneurodegenerative diseasesParkinson's diseaseAlzheimer's diseasebiomarkersneuron functionsynaptic vesiclesdementia
Research Aims
5AIM 01Investigate the impact of beta- and gamma-synucleins on alpha-synuclein's synaptic function.
AIM 02Analyze synaptic vesicle-binding changes as an early biomarker for synucleinopathies.
AIM 03Examine the implications of synuclein interactions on synaptic activity.
AIM 04Establish a timeline for changes in synaptic vesicle-binding in the gut and brain.
AIM 05Assess motor and gastrointestinal function in mouse models to correlate with synaptic changes.
Skills the Lab Values
mouse modelsbiochemical analysisimmunoblottingimmunohistochemistryquantitative data analysiselectrophysiologycell cultureprotein purificationmolecular cloning
Output against the department
Publications62bottom 15% of dept.565th of 671
this lab
most publishedleast published
Citations6.6kbottom 45% of dept.367th of 671
this lab
most citedleast cited
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