University of Michigan-Ann Arbor · BiochemistryBanerjee Lab
Ruma V Banerjee · Ann Arbor, Michigan
Research Focus
Dr. Ruma V Banerjee's lab at the University of Michigan focuses on the intricate process of Vitamin B12 trafficking in the cell. They study how this essential nutrient is guided by specific proteins, called chaperones, to reach its target enzymes in the cytoplasm and mitochondria. The lab is particularly interested in understanding the molecular mechanisms that underlie inherited defects in Vitamin B12 metabolism, which can lead to serious health issues.
Vitamin B12cobalaminchaperonesenzyme traffickinginherited metabolic disordersclinical geneticshomocystinuriamethylmalonic aciduriaMycobacterium tuberculosis
Research Aims
3AIM 01Elucidate how chaperones direct Vitamin B12 traffic in the cell.
AIM 02Investigate the transfer mechanism of Vitamin B12 between proteins.
AIM 03Study the molecular interactions that allow Vitamin B12 to enter and exit mitochondria.
Skills the Lab Values
Molecular cloningProtein purificationEnzyme kineticsSpectroscopic analysisMolecular modelingCellular assaysClinical data integrationBioinformaticsGene expression analysisChemical synthesis
Output against the department
Publications478top 9% of dept.37th of 402
this lab
most publishedleast published
Citations27ktop 14% of dept.57th of 402
this lab
most citedleast cited
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