University of Texas Southwestern Medical Center · BiologyCalcium Cognition Lab
James S Malter · Dallas, Texas
Research Focus
Dr. James S. Malter's lab focuses on understanding how calcium signaling affects neuron health in Alzheimer's disease. The team is studying the entorhinal cortex and hippocampus to identify mechanisms that contribute to memory deficits. By investigating specific proteins involved in calcium regulation, they aim to find potential treatments to improve cognitive function in early stages of Alzheimer's disease.
calcium signalingAlzheimer's diseaseentorhinal cortexhippocampussynaptic dysfunctioncalcineurintherapeutic agents
Research Aims
4AIM 01Investigate how calcium dysregulation impacts neuron function in Alzheimer's disease.
AIM 02Explore the role of calcineurin and Pin1 in synaptic communication.
AIM 03Determine the effects of calcium signaling normalization on neuron stability.
AIM 04Assess the use of CaN inhibitors as potential treatments for early Alzheimer's.
Skills the Lab Values
molecular imagingelectrophysiologybehavioral assaysbiochemical techniquesmouse modelsmicroscopydata analysisresearch design
Output against the department
Publications166top 40% of dept.412th of 1,033
this lab
most publishedleast published
Citations7.2ktop 50% of dept.518th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.