Brandeis University · BiologyKadener CircRNA Lab
Sebastian Kadener · Waltham, Massachusetts
Research Focus
Dr. Sebastian Kadener's lab at Brandeis University focuses on understanding the role of circular RNAs (circRNAs) in the aging process, particularly how they affect brain function and contribute to neurodegenerative diseases. The research combines biochemical and genetic techniques to explore how circRNAs influence lifespan and healthspan, helping to uncover the complex relationship between RNA metabolism and aging-related changes in the nervous system.
circRNAsagingneurodegenerative diseasesRNA metabolismlifespanhealthspan
Research Aims
3AIM 01Investigate the mechanisms behind aging-promoting circRNAs.
AIM 02Determine the role and requirements for circRNA translation in aging.
AIM 03Explore the relationship between FOXO regulation and circRNAs in aging.
Skills the Lab Values
biochemical assaysgenetic knockdownRNA sequencingcell culturetranscriptomicsDrosophila geneticsdata analysismolecular cloningexperimental design
Output against the department
Publications99bottom 35% of dept.675th of 1,033
this lab
most publishedleast published
Citations15ktop 25% of dept.261st of 1,033
this lab
most citedleast cited
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