AECAlbert Einstein College of Medicine · Biology
RUNX1 and Hematopoiesis Research Unit
Kristy Stengel · Bronx, New York
Research Focus
Kristy Stengel's lab focuses on understanding how the RUNX1 transcription factor regulates the development of blood cells and its links to blood disorders, such as familial platelet disorder and blood cancer. The lab utilizes innovative techniques to examine how RUNX1 interacts with other proteins to control gene expression that is critical for blood cell formation and function. By employing cell lines and engineered mouse models, they aim to uncover the mechanisms behind RUNX1's role in hematopoiesis, contributing to our understanding of genetic blood conditions.
RUNX1hematopoiesistranscription factorsblood disordersgene regulationmouse modelsplatelet productionmalignancy predispositionCRISPR
Research Aims
5AIM 01Identify RUNX1 target genes involved in hematopoiesis.
AIM 02Understand the cooperative relationships of RUNX1 with other transcription factors.
AIM 03Analyze the impact of RUNX1 depletion on blood stem cell development.
AIM 04Utilize mouse models to study the in vivo effects of RUNX1 loss.
AIM 05Investigate the link between RUNX1 mutations and familial blood disorders.
Skills the Lab Values
gene editingChIP-seqcell culturemouse modelstranscriptional analysisbiochemical assaysmolecular cloningprotein taggingflow cytometry
Output against the department
Publications87bottom 28% of dept.740th of 1,033
this lab
most publishedleast published
Citations2.3kbottom 16% of dept.863rd of 1,033
this lab
most citedleast cited
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