Harvard University · BiochemistryKruse Lab
Andrew Kruse · Cambridge, Massachusetts
Research Focus
Dr. Andrew Kruse's lab at Harvard Medical School focuses on understanding the molecular mechanisms behind bacterial cell wall synthesis. They study essential enzymes responsible for creating and maintaining the cell wall, which are potential targets for new antibiotics. By using advanced techniques in structural biology and single-molecule fluorescence, the lab aims to uncover how these enzymes are activated and regulated, paving the way for antibiotic development.
bacterial cell wallantibioticstransglycosylasestranspeptidasesstructural biologysingle-molecule fluorescenceantibiotic discoveryenzymatic activationcell wall synthases
Research Aims
4AIM 01Investigate the structural dynamics of SEDS-bPBPs and their regulatory partners.
AIM 02Define the mechanism of allosteric activation of aPBPs by lipoprotein cofactors.
AIM 03Explore the enzymatic activities central to bacterial cell wall synthesis.
AIM 04Develop a comprehensive understanding of essential cell wall synthases for future antibiotic discovery.
Skills the Lab Values
structural biology techniquessingle-molecule fluorescence microscopyprotein purificationcryoelectron microscopymicroscopyenzyme kineticsgenetic engineeringbacterial culturingbioinformatics
Output against the department
Publications214top 37% of dept.148th of 402
this lab
most publishedleast published
Citations20ktop 20% of dept.81st of 402
this lab
most citedleast cited
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