UWMUniversity of Wisconsin-Madison · Biomedical Engineering
Neurogenetic Therapeutics Lab
Shaoqin - Gong · Madison, Wisconsin
Research Focus
Dr. Shaoqin Gong's lab at the University of Wisconsin-Madison focuses on developing new treatments for Alzheimer's disease using advanced genetic engineering techniques. They aim to create non-viral nanovectors that can effectively deliver CRISPR genome editing tools across the blood-brain barrier, which is crucial for treating neurodegenerative diseases that affect large areas of the brain. The lab's innovative approach seeks to improve safety and efficiency in gene delivery, potentially leading to new therapeutic options for Alzheimer's patients.
CRISPRAlzheimer's Diseasegene therapynanotechnologyblood-brain barrier
Research Aims
5AIM 01Develop non-viral nanovectors for gene delivery to the brain
AIM 02Optimize brain-targeting ligands for effective therapy
AIM 03Evaluate the efficacy and safety of gene therapy in animal models
AIM 04Monitor behavioral and pathological changes in Alzheimer's models
AIM 05Test the application of nanovectors for other neurodegenerative diseases.
Skills the Lab Values
CRISPRgene editingnanoparticle engineeringanimal modelstwo-photon imaging
Output against the department
Publications250top 39% of dept.233rd of 595
this lab
most publishedleast published
Citations18ktop 19% of dept.114th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.