Santa Clara University · ChemistryLaboratory of ADP-Ribosylation Research
Ian O'Brien Carter-O'Connell · Santa Clara, California
Research Focus
Dr. Ian O'Brien Carter-O'Connell's lab at Santa Clara University focuses on understanding how a specific type of chemical modification in proteins, called ADP-ribosylation, works in cells. The research explores how this modification affects key biological processes, particularly in viruses and related diseases. The lab aims to create novel therapeutic approaches that can interrupt harmful viral activities by targeting the enzymes that process ADP-ribose, providing insights into mechanisms that could lead to new treatments.
ADP-ribosylationPARP14PARP15viral glycohydrolasespeptide-based inhibitorssignal transductionbiochemical pathwaysantiviral agentspost-translational modification
Research Aims
3AIM 01Identify auto-modification sites on PARP14 and PARP15 to link ADP-ribosylation events to cellular effects.
AIM 02Develop selective inhibitors targeting viral glycohydrolases using modified peptide sequences.
AIM 03Map the biochemical pathway transforming ADP-ribose to phosphoribose and investigate its role in antiviral responses.
Skills the Lab Values
PCRcell cultureprotein purificationpeptide synthesismass spectrometrybiochemical assaysstructure-activity relationship (SAR) analysisbioinformaticsviral infection models
Output against the department
Publications14bottom 2% of dept.211th of 216
this lab
most publishedleast published
Citations436bottom 4% of dept.207th of 216
this lab
most citedleast cited
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