Rutgers University-New Brunswick · BiologyDel Re Cardiology Lab
Dominic P Del Re · New Brunswick, New Jersey
Research Focus
Dr. Dominic P Del Re's lab focuses on understanding the molecular mechanisms behind heart failure, particularly how metabolic dysfunction contributes to the disease. The lab investigates the role of the tumor suppressor Neurofibromin 2 (NF2) and its interaction with specific transcription factors to promote heart health under stress. By establishing new potential therapeutic targets, the research aims to improve treatment strategies for heart failure, thereby addressing a major global health issue.
heart failuremetabolic dysfunctionNeurofibromin 2transcriptional regulationmitochondrial respirationtherapeutic strategiesERRbERRgcardiomyocytes
Research Aims
3AIM 01Establish evidence of NF2 as a key regulator of cardiac metabolism during pressure overload.
AIM 02Investigate the molecular interaction between NF2 and Zscan21 in regulating mitochondrial function in cardiomyocytes.
AIM 03Determine the therapeutic potential of normalizing NF2 levels to improve heart function in heart failure models.
Skills the Lab Values
cell cultureproteomicstranscriptome profilinggene expression analysismouse modelsmolecular cloningWestern blottingmetabolic assaysstress testingin vivo experimentation
Output against the department
Publications84bottom 26% of dept.761st of 1,033
this lab
most publishedleast published
Citations11ktop 34% of dept.355th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.