University at Albany · BiologyFibrosis and Regeneration Lab
Melinda Larsen · Albany, New York
Research Focus
Dr. Melinda Larsen's lab focuses on understanding and treating fibrosis, particularly in salivary glands damaged by radiation or diseases like Sjogren's Syndrome. They explore how certain cells contribute to fibrosis and investigate potential therapies that could improve organ regeneration. This research is crucial as fibrosis is a major health issue, contributing to significant morbidity and mortality.
fibrosissalivary glandextracellular matrixstem cellsregenerative medicineTGF signalingbiomarkerstissue healingorganoids
Research Aims
5AIM 01Identify how TGF modulation affects fibrosis in salivary glands.
AIM 02Investigate the potential of cell-specific manipulation of TGF signaling in fibroblasts.
AIM 03Test the effectiveness of scaffold-mediated transplantation of mesenchymal stem cells.
AIM 04Differentiate between reversible and irreversible fibrosis through biomarker analysis.
AIM 05Apply advanced techniques to study cell responses during fibrosis progression and recovery.
Skills the Lab Values
single-cell RNA sequencingcell culturemouse modelsproteomicsquantitative histologytransplantation techniquesexosome analysisscaffold engineeringgene expression analysis
Output against the department
Publications122bottom 44% of dept.582nd of 1,033
this lab
most publishedleast published
Citations6.7kbottom 47% of dept.546th of 1,033
this lab
most citedleast cited
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