University of California-Berkeley · BiochemistryPortnoy Lab
Daniel A Portnoy · Berkeley, California
Research Focus
Dr. Daniel Portnoy's lab at UC Berkeley studies how certain bacteria, like Listeria and Mycobacterium tuberculosis, evade our immune systems. They focus on understanding both the bacteria's tricks to cause disease and the body's responses to them. This research aims to develop better vaccines and treatments for bacterial infections by leveraging insights into the interactions between bacteria and immune responses.
intracellular pathogensinnate immunityadaptive immunityMycobacterium tuberculosisListeria monocytogenesvaccine developmentpathogenesistype I interferonimmunologycyclic-di-nucleotide
Research Aims
5AIM 01Investigate how intracellular pathogens manipulate host innate immune responses.
AIM 02Characterize immune pathways activated by bacterial metabolites and virulence factors.
AIM 03Develop novel vaccine strategies against Mycobacterium tuberculosis and Listeria monocytogenes.
AIM 04Explore the dual roles of type I interferons in bacterial infections.
AIM 05Evaluate the effectiveness of cyclic-di-nucleotide based vaccines.
Skills the Lab Values
cell culturemouse modelsimmunological assaysWestern blottingflow cytometryprotein purificationbacterial geneticsin vivo imagingELISARNA sequencing
Output against the department
Publications219top 36% of dept.144th of 402
this lab
most publishedleast published
Citations27ktop 14% of dept.55th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.