UMCUniversity of Massachusetts Chan Medical School · Genetics
Walhout Lab
A. J. Marian Walhout · Worcester, Massachusetts
Research Focus
Dr. A. J. Marian Walhout's research lab focuses on understanding how metabolism and gene expression interact in living organisms, particularly using the model organism C. elegans, a small roundworm. By investigating how genetic mutations and dietary factors affect metabolic processes and gene activity, the lab aims to shed light on the mechanisms behind various human diseases. This research not only explores basic biological principles but also has the potential to inform treatments for metabolic disorders in humans.
C. elegansgene regulationmetabolisminborn errors of metabolismmetabolomicsdietmicrobiotagene expression
Research Aims
5AIM 01Investigate how gene expression controls metabolic processes in C. elegans.
AIM 02Determine the effects of dietary changes on metabolism and gene expression.
AIM 03Explore the relationship between metabolic disturbances and human diseases.
AIM 04Utilize genetic mutants to study inborn errors of metabolism.
AIM 05Analyze the influence of microbiota on metabolic and genetic interactions.
Skills the Lab Values
genetic screeninggene expression profilingmetabolomicsC. elegans handlingdata analysisbioinformaticscell cultureexperimental design
Output against the department
Publications188top 45% of dept.116th of 259
this lab
most publishedleast published
Citations17ktop 34% of dept.89th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.