Columbia University in the City of New York · BiologyThe Metabolic Sentinel Lab
Wei Gu · New York, New York
Research Focus
Dr. Wei Gu's lab at Columbia University focuses on understanding how the p53 tumor suppressor protein regulates metabolism to inhibit tumor growth. By investigating the metabolic pathways influenced by p53, the lab aims to find new therapeutic targets that can effectively suppress cancer while minimizing damage to healthy tissues. This research is particularly important as it explores unconventional mechanisms of tumor suppression, which may open up new avenues for cancer treatment.
p53tumor suppressionmetabolismferroptosiscancer therapymetabolic regulationapoptosiscell cyclecancer cells
Research Aims
5AIM 01Define the p53-mediated metabolic regulation program required for tumor suppression.
AIM 02Investigate the role of p53 in regulating novel pathways like ferroptosis.
AIM 03Identify specific metabolic vulnerabilities in cancer cells.
AIM 04Assess the impact of manipulating p53 on tumor growth.
AIM 05Evaluate the toxicity of p53-targeted therapies on normal tissues.
Skills the Lab Values
cell culturemolecular cloningWestern blotPCRmetabolomicsflow cytometryanimal modelsdrug screeningbioinformatics
Output against the department
Publications245top 25% of dept.255th of 1,033
this lab
most publishedleast published
Citations50ktop 6% of dept.57th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.