University of Michigan-Ann Arbor · PhysiologyRainey Lab
William E Rainey · Ann Arbor, Michigan
Research Focus
Dr. William E. Rainey’s lab at the University of Michigan focuses on understanding how the adrenal gland produces different hormones. They study the processes that lead to the formation of specific cell types in the adrenal cortex, particularly how progenitor cells develop into hormone-producing cells. The research aims to uncover the molecular mechanisms behind these transformations, which could help in understanding adrenal-related health issues.
adrenal glandzonationhormone productionadrenal cortexcell differentiationprogenitor cellssteroidogenesismulti-omicsnuclear receptors
Research Aims
5AIM 01Investigate how angiotensin II influences the differentiation of adrenal progenitor cells into aldosterone-producing cells.
AIM 02Define the molecular mechanisms for the conversion of zona fasciculata cells into zona reticularis cells that produce DHEAS.
AIM 03Explore how specific nuclear receptors regulate steroidogenic enzyme expression in adrenal cells.
AIM 04Utilize advanced multi-omics techniques to dissect cellular transformations in the adrenal cortex.
AIM 05Improve understanding of adrenal homeostasis and potential treatments for adrenal diseases.
Skills the Lab Values
single cell RNA sequencingATAC-seqcut-and-tag sequencinglineage tracingspatial transcriptomicshigh-resolution mass spectrometry imagingcell culture techniquesdata analysis with Pythonanimal models (mice)human tissue handling
Output against the department
Publications481top 6% of dept.17th of 286
this lab
most publishedleast published
Citations25ktop 10% of dept.28th of 286
this lab
most citedleast cited
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